A glue application machine is not a challenging machine to operate. There has to be a worker present for the set-up of the pressure level and speed. Since glue spreaders have been associated with certain negative health impacts, as the fluids they use often contain solvents (for example, adhesives or varnish) that can be hazardous to one's health, it is recommended to install an exhaust extraction system as a gluing machine accessory.
The rollers can also pose a hazard, as they could inflict injury, so it is important to read the safety instructions before any work is done with a wood gluing machine. Cleaning a glue spreading machine requires a lot of effort and it should be done on a regular, often daily, basis and no part of the gluing machine should be neglected. Leftovers and dried up fluids can very quickly make the glue spreader unusable. Safety measures must also be taken during the cleaning of the industrial gluing machine, as cleaning products are often very strong. Personal protection should be worn, with relation to the fluid that is being cleaned.